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Who was studied 3,037,499 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.00708 higher (95% confidence interval 0.005-0.0091); p = 2 × 10−11.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.
What each result means
A/ATwo copies of the version the research linked to Educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Educational attainment. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Educational attainment. This is the starting point the study compared everyone against.
Nature genetics · 2022 · PMID 35361970 · open access
Questions about rs7531138
What is rs7531138?
rs7531138 is a single position in the genome, in or near the DPYD gene. Published research associates it with educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7531138 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does rs7531138 affect how medicines work?
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs7531138 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7531138 come from?
GWAS Catalog, Nature genetics 2022, PMID:35361970. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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