Sensitive

Renal cell carcinoma

KDELC2 · rs74911261

Where this position leads

What the study found

Who was studied 10,784 European ancestry cases, 20,406 European ancestry controls; replicated in 3,182 European ancestry cases, 6,301 European ancestry controls.

The effect Each copy of the A allele carried 1.41 times the odds of Renal cell carcinoma (95% confidence interval 1.27—1.57); p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 11, band 11q22.3 — a missense change in POGLUT3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Renal cell carcinoma compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Renal cell carcinoma.

G/G Published research associates this genotype with typical/baseline likelihood of Renal cell carcinoma — no copies of the reported risk allele.

Source

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Scelo G, Purdue MP, Brown KM, Johansson M, Wang Z, Eckel-Passow JE, Ye Y, Hofmann JN, Choi J, Foll M, Gaborieau V, Machiela MJ

and 111 more — show all

Colli LM, Li P, Sampson JN, Abedi-Ardekani B, Besse C, Blanche H, Boland A, Burdette L, Chabrier A, Durand G, Le Calvez-Kelm F, Prokhortchouk E, Robinot N, Skryabin KG, Wozniak MB, Yeager M, Basta-Jovanovic G, Dzamic Z, Foretova L, Holcatova I, Janout V, Mates D, Mukeriya A, Rascu S, Zaridze D, Bencko V, Cybulski C, Fabianova E, Jinga V, Lissowska J, Lubinski J, Navratilova M, Rudnai P, Szeszenia-Dabrowska N, Benhamou S, Cancel-Tassin G, Cussenot O, Baglietto L, Boeing H, Khaw KT, Weiderpass E, Ljungberg B, Sitaram RT, Bruinsma F, Jordan SJ, Severi G, Winship I, Hveem K, Vatten LJ, Fletcher T, Koppova K, Larsson SC, Wolk A, Banks RE, Selby PJ, Easton DF, Pharoah P, Andreotti G, Freeman LEB, Koutros S, Albanes D, Männistö S, Weinstein S, Clark PE, Edwards TL, Lipworth L, Gapstur SM, Stevens VL, Carol H, Freedman ML, Pomerantz MM, Cho E, Kraft P, Preston MA, Wilson KM, Michael Gaziano J, Sesso HD, Black A, Freedman ND, Huang WY, Anema JG, Kahnoski RJ, Lane BR, Noyes SL, Petillo D, Teh BT, Peters U, White E, Anderson GL, Johnson L, Luo J, Buring J, Lee IM, Chow WH, Moore LE, Wood C, Eisen T, Henrion M, Larkin J, Barman P, Leibovich BC, Choueiri TK, Mark Lathrop G, Rothman N, Deleuze JF, McKay JD, Parker AS, Wu X, Houlston RS, Brennan P, Chanock SJ

Nature communications · 2017 · PMID 28598434 · open access

Questions about rs74911261

What is rs74911261?

rs74911261 is a single position in the genome, in or near the KDELC2 gene. Published research associates it with renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs74911261 linked to?

On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs74911261 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74911261 come from?

GWAS Catalog, Nat Commun 2017, PMID:28598434. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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