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SELP protein levels

F5 · rs74581078

Where this position leads

Drug: Combined hormonal contraceptives

rs74581078 Drug: Combined hormonal contraceptives Combined hormonal contraceptives Drug rs74581078 rs74581078 F5

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.178 higher (95% confidence interval 0.13-0.23); p = 3 × 10−15.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — in an intron of F5.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of SELP protein levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with SELP protein levels.
G/G Published research associates this genotype with typical/baseline likelihood of SELP protein levels — no copies of the reported risk allele.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs74581078

What is rs74581078?

rs74581078 is a single position in the genome, in or near the F5 gene. Published research associates it with selp protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs74581078 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs74581078 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs74581078 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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SELP protein levels (rs74581078). MyGeneLog™. https://www.mygenelog.com/variants/rs74581078

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