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Who was studied 51,256 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 370,487 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls; replicated in 73,088 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry cases, 79,827 African, African American, East Asian, South Asian, European, Middle Eastern, admixed American, other or other admixed ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.131 lower (95% confidence interval 0.092-0.171); p = 8 × 10−11.
How common The C allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 4, band 4p16.3 — in an intron of PCGF3.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2024 · PMID 39379762 · open access
Questions about rs73221131
What is rs73221131?
rs73221131 is a single position in the genome, in or near the PCGF3 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73221131 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs73221131 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73221131 come from?
GWAS Catalog, Nature genetics 2024, PMID:39379762. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs73221131). MyGeneLog™. https://www.mygenelog.com/variants/rs73221131