Primary open angle glaucoma (multi-trait analysis)
MECOM · rs73174388
0 91224Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others4Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied at least 29,241 European ancestry cases, at least 350,181 European ancestry controls (MTAG boosted by vertical cup-to-disc ratio and intraocular pressure samples), 6,935 Asian ancestry cases, 39,588 Asian ancestry controls, 3,281 African ancestry cases, 2,791 African ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.106 higher (95% confidence interval 0.072-0.14); p = 6 × 10−10.
Where it sits Chromosome 3, band 3q26.2 — in an intron of MECOM.
What each result means
C/CNo copy of the version the research linked to Primary open angle glaucoma (multi-trait analysis). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Primary open angle glaucoma (multi-trait analysis). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Primary open angle glaucoma (multi-trait analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 37386247 · open access
Questions about rs73174388
What is rs73174388?
rs73174388 is a single position in the genome, in or near the MECOM gene. Published research associates it with primary open angle glaucoma (multi-trait analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs73174388 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs73174388 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs73174388 come from?
GWAS Catalog, Nature genetics 2023, PMID:37386247. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91224Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others4Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Primary open angle glaucoma (multi-trait analysis) (rs73174388). MyGeneLog™. https://www.mygenelog.com/variants/rs73174388