Standard

Total bilirubin levels

SLCO1B1 · rs7296435

Where this position leads

Drugs: Statins, Ticagrelor

rs7296435 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs7296435 rs7296435 SLCO1B1

What the study found

Who was studied 341,077 European ancestry individuals, 5,978 African ancestry individuals, 7,313 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0487 lower (95% confidence interval 0.04-0.057); p = 6 × 10−30.

Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.

What each result means

A/A No copy of the version the research linked to Total bilirubin levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Total bilirubin levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Total bilirubin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7296435

What is rs7296435?

rs7296435 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with total bilirubin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs7296435 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs7296435 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7296435 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total bilirubin levels (rs7296435). MyGeneLog™. https://www.mygenelog.com/variants/rs7296435

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