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Refractive error

BCAS3 · rs7224107

Where this position leads

Condition: Myopia

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,495,159 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0157 SD unit lower (95% confidence interval 0.01-0.021); p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 17, band 17q23.2 — in an intron of BCAS3.

How common each version is

CT

Korean KRGDB

C 86.8% · T 13.2%

Korean Korea4K

C 86.3% · T 13.7%

Korean Korea1K

C 85.5% · T 14.5%

Japanese ToMMo

C 85.8% · T 14.2%

Vietnamese

C 76.4% · T 23.6%

World gnomAD

C 89.8% · T 10.2%

World 1000 Genomes

C 87.3% · T 12.7%

World TOPMed

C 89.4% · T 10.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Refractive error. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction

Cheng FF, Liu X, Mi H, Wang L, Ma R, Guo Y, Sidorenko J, Jiang C, Islam T, Meguro A, Hikino K, Ishikawa Y

and 15 more — show all

Tang S, Li T, Chen R, Wang L, Mägi R, Metspalu A, Takeuchi M, Mizuki N, Choquet H, Jin ZB, Chen G, Zhou K, Terao C, Zeng J, Yang J

Estonian Biobank Research Team · 23andMe Research Team

Nature genetics · 2026 · PMID 42009823 · open access

Questions about rs7224107

What is rs7224107?

rs7224107 is a single position in the genome, in or near the BCAS3 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7224107 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

Does having rs7224107 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7224107 come from?

GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Refractive error (rs7224107). MyGeneLog™. https://www.mygenelog.com/variants/rs7224107

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