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Triglycerides in chylomicrons and extremely large VLDL

GAS6 · rs7140110

Where this position leads

Condition: Age-Related Macular Degeneration

rs7140110 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs7140110 rs7140110 GAS6

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.00508 higher (95% confidence interval 0.0034-0.0067); p = 7 × 10−10.

How common The C allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 13, band 13q34 — in a non-coding transcript of GAS6.

What each result means

C/C Two copies of the version the research linked to Triglycerides in chylomicrons and extremely large VLDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Triglycerides in chylomicrons and extremely large VLDL. That is a smaller link than two copies.
T/T No copy of the version the research linked to Triglycerides in chylomicrons and extremely large VLDL. This is the starting point the study compared everyone against.
Source

Questions about rs7140110

What is rs7140110?

rs7140110 is a single position in the genome, in or near the GAS6 gene. Published research associates it with triglycerides in chylomicrons and extremely large vldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7140110 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs7140110 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7140110 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Triglycerides in chylomicrons and extremely large VLDL (rs7140110). MyGeneLog™. https://www.mygenelog.com/variants/rs7140110

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