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Who was studied 354,862 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0154 lower (95% confidence interval 0.0099-0.0209); p = 4 × 10−8.
How common The C allele had a frequency of about 81% in the people studied.
Where it sits Chromosome 12, band 12q24.23 — in an intron of KSR2.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Depressive symptoms (MTAG) — no copies of the reported risk allele.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depressive symptoms (MTAG).
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depressive symptoms (MTAG) compared to the general population.
Nature genetics · 2018 · PMID 29292387 · open access
Questions about rs7134419
What is rs7134419?
rs7134419 is a single position in the genome, in or near the KSR2 gene. Published research associates it with depressive symptoms (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7134419 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs7134419 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7134419 come from?
GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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