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Who was studied 121,172 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0261 SD unit higher (95% confidence interval 0.018-0.034); p = 7 × 10−10.
How common The A allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 11, band 11q22.3 — in an intron of GRIA4.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Refractive error compared to the general population.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Refractive error.
C/CPublished research associates this genotype with typical/baseline likelihood of Refractive error — no copies of the reported risk allele.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs7115736
What is rs7115736?
rs7115736 is a single position in the genome, in or near the GRIA4 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7115736 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs7115736 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7115736 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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