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Tyrosine levels

JMJD1C · rs7077580

Where this position leads

Condition: Age-Related Macular Degeneration

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.000921 higher (95% confidence interval 0.00069-0.00116); p = 1 × 10⁻¹⁴.

How common The A allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 10, band 10q21.3 — in an intron of JMJD1C.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Tyrosine levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Tyrosine levels.

G/G Published research associates this genotype with typical/baseline likelihood of Tyrosine levels — no copies of the reported risk allele.

Source

Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration

Farashi S, Bonelli R, Jackson VE, Ansell BRE, Guymer RH, Bahlo M

Ophthalmology science · 2024 · PMID 39091897 · open access

Questions about rs7077580

What is rs7077580?

rs7077580 is a single position in the genome, in or near the JMJD1C gene. Published research associates it with tyrosine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7077580 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs7077580 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7077580 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Tyrosine levels (rs7077580). MyGeneLog™. https://www.mygenelog.com/variants/rs7077580

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