Gene Knowledge Graph
UTC
Sensitive

Type 2 diabetes with neurological manifestations (PheCode 250.24)

ZMIZ1 · rs703969

Where this position leads

Condition: Type 2 Diabetes

rs703969 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs703969 rs703969 ZMIZ1

What the study found

Who was studied 16,638 African American or Afro-Caribbean cases, 99,303 African American or Afro-Caribbean controls, 7,320 Hispanic or Latin American cases, 50,236 Hispanic or Latin American controls, 443 East Asian ancestry cases, 6,209 East Asian ancestry controls, 59,205 European ancestry cases, 375,439 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0446 higher (95% confidence interval 0.031-0.058); p = 6 × 10−12.

How common The G allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 10, band 10q22.3 — in an intron of ZMIZ1.

What each result means

C/C No copy of the version the research linked to Type 2 diabetes with neurological manifestations (PheCode 250.24). This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Type 2 diabetes with neurological manifestations (PheCode 250.24). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Type 2 diabetes with neurological manifestations (PheCode 250.24). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs703969

What is rs703969?

rs703969 is a single position in the genome, in or near the ZMIZ1 gene. Published research associates it with type 2 diabetes with neurological manifestations (phecode 250.24). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs703969 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs703969 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs703969 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes with neurological manifestations (PheCode 250.24) (rs703969). MyGeneLog™. https://www.mygenelog.com/variants/rs703969

← See all variants