0 304823112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot8Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others12Total30Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,458,999 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 7.18 higher; p = 7 × 10−13.
Where it sits Chromosome 3, band 3p24.3 — in an intron of PLCL2.
What each result means
A/ATwo copies of the version the research linked to Substance use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Substance use disorder. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Substance use disorder. This is the starting point the study compared everyone against.
Molecular psychiatry · 2026 · PMID 41057643 · open access
Questions about rs6800583
What is rs6800583?
rs6800583 is a single position in the genome, in or near the PLCL2 gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6800583 linked to?
On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs6800583 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6800583 come from?
GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 304823112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI4Microsoft · Copilot8Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others12Total30Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Substance use disorder (rs6800583). MyGeneLog™. https://www.mygenelog.com/variants/rs6800583