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Who was studied 374,971 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.8 z score lower; p = 1 × 10−11.
How common The A allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 2, band 2p23.3 — in an intron of ATAD2B.
What each result means
A/ATwo copies of the version the research linked to Feeling fed-up. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Feeling fed-up. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Feeling fed-up. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs6718635
What is rs6718635?
rs6718635 is a single position in the genome, in or near the ATAD2B gene. Published research associates it with feeling fed-up. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6718635 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs6718635 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6718635 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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