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IgA nephropathy

HLA-DRB1 · rs660895

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−19, with 7 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,434 Han Chinese ancestry cases, 4,270 Han Chinese ancestry controls; replicated in 2,703 Han Chinese ancestry cases, 3,464 Han Chinese ancestry controls.

The effect Each copy of the G allele carried 1.34 times the odds of IgA nephropathy (95% confidence interval 1.26-1.42); p = 4 × 10−20.

How common The G allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 18.6 kb from HLA-DQA1.

How common each version is

AG
Korean KRGDB
A 72.7% · G 27.3%
Korean Korea4K
A 74.0% · G 26.0%
Japanese ToMMo
A 71.2% · G 28.8%
World gnomAD
A 80.5% · G 19.5%
World 1000 Genomes
A 80.2% · G 19.9%
World TOPMed
A 79.8% · G 20.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to IgA nephropathy. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to IgA nephropathy. That is a smaller link than two copies.
G/G Two copies of the version the research linked to IgA nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy
Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y, Foo JN, Wang W, Li ZJ
and 13 more — show all
Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH, Liu JJ
Nature genetics · 2011 · PMID 22197929

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

IgA nephropathy (rs660895). MyGeneLog™. https://www.mygenelog.com/variants/rs660895

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