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Total phospholipids in lipoprotein particles

GAS6 · rs6602911

Where this position leads

Condition: Age-Related Macular Degeneration

rs6602911 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs6602911 rs6602911 GAS6

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0156 higher (95% confidence interval 0.011-0.02); p = 2 × 10−11.

How common The T allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 13, band 13q34 — in a non-coding transcript of GAS6.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Total phospholipids in lipoprotein particles — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total phospholipids in lipoprotein particles.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total phospholipids in lipoprotein particles compared to the general population.
Source

Questions about rs6602911

What is rs6602911?

rs6602911 is a single position in the genome, in or near the GAS6 gene. Published research associates it with total phospholipids in lipoprotein particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6602911 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs6602911 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6602911 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total phospholipids in lipoprotein particles (rs6602911). MyGeneLog™. https://www.mygenelog.com/variants/rs6602911

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