OPCML · rs6590712
Where this position leads
Condition: Substance Use Disorder
What the study found
Who was studied 1,458,999 European ancestry individuals, 240,296 African ancestry individuals, 58,370 mixed American ancestry individuals.
The effect The reported allele is A; the catalogue records no effect size ; p = 1 × 10−8.
Where it sits Chromosome 11, band 11q25 — in an intron of OPCML.
rs6590712 is a single position in the genome, in or near the OPCML gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Substance use disorder (rs6590712). MyGeneLog™. https://www.mygenelog.com/variants/rs6590712