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Who was studied 521,594 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0134 SD unit lower (95% confidence interval 0.0093-0.0175); p = 2 × 10−10.
How common The T allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 2, band 2p14 — in an intron of MEIS1-AS3.
What each result means
A/ANo copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs6546232 is a single position in the genome, in or near the MEIS1-AS3 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6546232 linked to?
On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.
Does having rs6546232 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6546232 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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