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Spherical equivalent (joint analysis main effects and education interaction)

RASGRF1 · rs6495367

Where this position leads

Condition: Myopia

What the study found

Who was studied 2,604 Erasmus Rucphen population isolate individuals, 456 Sardinian population isolate individuals, 36,976 European ancestry individuals, 5,971 East Asian ancestry individuals, 2,256 Malay ancestry individuals, 2,088 Indian ancestry individuals.

The effect The reported allele is A; the catalogue records no effect size ; p = 5 × 10⁻⁶.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 15, band 15q25.1 — in an intron of RASGRF1.

What each result means

A/A Two copies of the version the research linked to Spherical equivalent (joint analysis main effects and education interaction). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Spherical equivalent (joint analysis main effects and education interaction). That is a smaller link than two copies.

G/G No copy of the version the research linked to Spherical equivalent (joint analysis main effects and education interaction). This is the starting point the study compared everyone against.

Source

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Fan Q, Verhoeven VJ, Wojciechowski R, Barathi VA, Hysi PG, Guggenheim JA, Höhn R, Vitart V, Khawaja AP, Yamashiro K, Hosseini SM, Lehtimäki T

and 142 more — show all

Lu Y, Haller T, Xie J, Delcourt C, Pirastu M, Wedenoja J, Gharahkhani P, Venturini C, Miyake M, Hewitt AW, Guo X, Mazur J, Huffman JE, Williams KM, Polasek O, Campbell H, Rudan I, Vatavuk Z, Wilson JF, Joshi PK, McMahon G, St Pourcain B, Evans DM, Simpson CL, Schwantes-An TH, Igo RP, Mirshahi A, Cougnard-Gregoire A, Bellenguez C, Blettner M, Raitakari O, Kähönen M, Seppala I, Zeller T, Meitinger T, Ried JS, Gieger C, Portas L, van Leeuwen EM, Amin N, Uitterlinden AG, Rivadeneira F, Hofman A, Vingerling JR, Wang YX, Wang X, Tai-Hui Boh E, Ikram MK, Sabanayagam C, Gupta P, Tan V, Zhou L, Ho CE, Lim W, Beuerman RW, Siantar R, Tai ES, Vithana E, Mihailov E, Khor CC, Hayward C, Luben RN, Foster PJ, Klein BE, Klein R, Wong HS, Mitchell P, Metspalu A, Aung T, Young TL, He M, Pärssinen O, van Duijn CM, Jin Wang J, Williams C, Jonas JB, Teo YY, Mackey DA, Oexle K, Yoshimura N, Paterson AD, Pfeiffer N, Wong TY, Baird PN, Stambolian D, Wilson JE, Cheng CY, Hammond CJ, Klaver CC, Saw SM, Rahi JS, Korobelnik JF, Kemp JP, Timpson NJ, Smith GD, Craig JE, Burdon KP, Fogarty RD, Iyengar SK, Chew E, Janmahasatian S, Martin NG, MacGregor S, Xu L, Schache M, Nangia V, Panda-Jonas S, Wright AF, Fondran JR, Lass JH, Feng S, Zhao JH, Khaw KT, Wareham NJ, Rantanen T, Kaprio J, Pang CP, Chen LJ, Tam PO, Jhanji V, Young AL, Döring A, Raffel LJ, Cotch MF, Li X, Yip SP, Yap MK, Biino G, Vaccargiu S, Fossarello M, Fleck B, Yazar S, Tideman JW, Tedja M, Deangelis MM, Morrison M, Farrer L, Zhou X, Chen W, Mizuki N, Meguro A, Mäkelä KM

Consortium for Refractive Error and Myopia

Nature communications · 2016 · PMID 27020472 · open access

Questions about rs6495367

What is rs6495367?

rs6495367 is a single position in the genome, in or near the RASGRF1 gene. Published research associates it with spherical equivalent (joint analysis main effects and education interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6495367 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

Does having rs6495367 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6495367 come from?

GWAS Catalog, Nat Commun 2016, PMID:27020472. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Spherical equivalent (joint analysis main effects and education interaction) (rs6495367). MyGeneLog™. https://www.mygenelog.com/variants/rs6495367

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