Sensitive

Crohn's disease

TNFSF15 · rs6478109

Where this position leads

What the study found

Who was studied 275 Korean ancestry cases, 2,369 Korean ancestry controls; replicated in 242 Korean ancestry cases, 1,066 Korean ancestry controls.

The effect Each copy of the G allele carried 2.08 times the odds of Crohn's disease (95% confidence interval 1.82-2.38); p = 5 × 10⁻²⁵.

How common The G allele had a frequency of about 51% in the people studied.

Where it sits Chromosome 9, band 9q32 — between genes, 0.4 kb from TNFSF15.

What each result means

A/A No copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

HLA-C*01 is a Risk Factor for Crohn's Disease

Jung ES, Cheon JH, Lee JH, Park SJ, Jang HW, Chung SH, Park MH, Kim TG, Oh HB, Yang SK, Park SH, Han JY

and 4 more — show all

Hong SP, Kim TI, Kim WH, Lee MG

Inflammatory bowel diseases · 2016 · PMID 26891255

What people read about alongside this

Gut and food intolerance1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs6478109

What is rs6478109?

rs6478109 is a single position in the genome, in or near the TNFSF15 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6478109 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs6478109?

Subjects that appear in the title or abstract of the same papers as this rsID include gut and food intolerance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs6478109 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6478109 come from?

GWAS Catalog, Inflamm Bowel Dis 2016, PMID:26891255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Crohn's disease (rs6478109). MyGeneLog™. https://www.mygenelog.com/variants/rs6478109

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