1 8215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 5,313 East Asian ancestry cases, 96,912 East Asian ancestry controls, 25,890 European ancestry cases, 743,585 European ancestry controls, 897 African American cases, 3,109 African American controls, 1,612 Hispanic or Latin American cases, 2,180 Hispanic or Latin American controls.
The effect
Each copy of the A allele carried 1.06 times the odds of Renal cell carcinoma (95% confidence interval 1.04-1.08); p = 1 × 10−8.
How common The A allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 4, band 4p15.2 — in an intron of PPARGC1A.
What each result means
A/ATwo copies of the version the research linked to Renal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Renal cell carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Renal cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2026 · PMID 42000752 · open access
Questions about rs6448226
What is rs6448226?
rs6448226 is a single position in the genome, in or near the PPARGC1A gene. Published research associates it with renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6448226 linked to?
On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs6448226 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6448226 come from?
GWAS Catalog, Nature communications 2026, PMID:42000752. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 8215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.