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Heart failure progression (time to cardiovascular mortality or heart failure hospitalisation)

EPB41L4B · rs62576378

Where this position leads

Condition: Heart Failure Progression

rs62576378 Condition: Heart Failure Progression Heart Failure Progression Condition rs62576378 rs62576378 EPB41L4B

What the study found

Who was studied 50,364 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 1.95 higher (95% confidence interval 1.3-2.61); p = 8 × 10−9.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 9, band 9q31.3 — in an intron of EPB41L4B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart failure progression (time to cardiovascular mortality or heart failure hospitalisation) compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart failure progression (time to cardiovascular mortality or heart failure hospitalisation).
T/T Published research associates this genotype with typical/baseline likelihood of Heart failure progression (time to cardiovascular mortality or heart failure hospitalisation) — no copies of the reported risk allele.
Source
Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study
Sunderland N, Asselin G, Henry A, Nelson CP, Lemieux Perreault LP, Asselbergs FW, Boersma E, Cappola TP, Chazara O, Chutkow W, Cyr MC, Gkatzionis A
and 46 more — show all
Gui H, Haefliger C, Hedman ÅK, Hillege H, Hyde CL, Kamanu FK, Kardys I, Koekemoer AL, Kraus WE, Lang CC, Malarstig A, Margulies KB, Marston NA, Melloni GEM, Morley MP, O'Donoghue ML, Owens AT, Paul DS, Tilling K, van der Harst P, van Setten J, van Vugt M, Verweij N, Veluchamy A, Wallentin L, Wang X, Xing H, Yang Y, White HD, Zannad F, Smith JG, Brunner-La Rocca HP, Lanfear DE, Mann DL, de Denus S, Tardif JC, Voors AA, Samani NJ, Ellinor PT, Ruff CT, Sabatine MS, Sattar N, McMurray JJV, Paternoster L, Dubé MP, Lumbers RT
Journal of the American College of Cardiology · 2026 · PMID 42017882 · open access

Questions about rs62576378

What is rs62576378?

rs62576378 is a single position in the genome, in or near the EPB41L4B gene. Published research associates it with heart failure progression (time to cardiovascular mortality or heart failure hospitalisation). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62576378 linked to?

On MyGeneLog this position is linked to Heart Failure Progression. The research behind each link, and its sources, are set out on that condition page.

Does having rs62576378 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62576378 come from?

GWAS Catalog, GWAS Catalog n.d., PMID:42017882. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure progression (time to cardiovascular mortality or heart failure hospitalisation) (rs62576378). MyGeneLog™. https://www.mygenelog.com/variants/rs62576378

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