Sensitive

Type 2 diabetes

TFAP2B · rs62405419

Where this position leads

Condition: Type 2 Diabetes

rs62405419 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs62405419 rs62405419 TFAP2B

What the study found

Who was studied 38,841 European ancestry cases, 451,248 European ancestry controls, 45,383 East Asian ancestry cases, 132,032 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0565 higher (95% confidence interval 0.04-0.073); p = 5 × 10−12.

Where it sits Chromosome 6, band 6p12.3 — in an intron of TFAP2B.

What each result means

G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs62405419

What is rs62405419?

rs62405419 is a single position in the genome, in or near the TFAP2B gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62405419 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs62405419 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62405419 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs62405419). MyGeneLog™. https://www.mygenelog.com/variants/rs62405419

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