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Glaucoma (primary open-angle)

LHPP · rs61870251

Where this position leads

Condition: Glaucoma

rs61870251 Condition: Glaucoma Glaucoma Condition rs61870251 rs61870251 LHPP

What the study found

Who was studied 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls.

The effect Each copy of the A allele carried 0.87 times the odds of Glaucoma (primary open-angle) (95% confidence interval 0.82-0.91); p = 2 × 10−10.

Where it sits Chromosome 10, band 10q26.13 — in an intron of LHPP.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glaucoma (primary open-angle) compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glaucoma (primary open-angle).
C/C Published research associates this genotype with typical/baseline likelihood of Glaucoma (primary open-angle) — no copies of the reported risk allele.
Source
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP Jr
and 67 more — show all
Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ, Karjalainen J, Uebe S, Melles RB, Nair KS, Luben R, Simcoe M, Amersinghe N, Cree AJ, Hohn R, Poplawski A, Chen LJ, Rong SS, Aung T, Vithana EN, Tamiya G, Shiga Y, Yamamoto M, Nakazawa T, Currant H, Birney E, Wang X, Auton A, Lupton MK, Martin NG, Ashaye A, Olawoye O, Williams SE, Akafo S, Ramsay M, Hashimoto K, Kamatani Y, Akiyama M, Momozawa Y, Foster PJ, Khaw PT, Morgan JE, Strouthidis NG, Kraft P, Kang JH, Pang CP, Pasutto F, Mitchell P, Lotery AJ, Palotie A, van Duijn C, Haines JL, Hammond C, Pasquale LR, Klaver CCW, Hauser M, Khor CC, Mackey DA, Kubo M, Cheng CY, Craig JE, MacGregor S, Wiggs JL
NEIGHBORHOOD consortium · ANZRAG consortium · Biobank Japan project · FinnGen study · UK Biobank Eye and Vision Consortium · GIGA study group · 23 and Me Research Team
Nature communications · 2021 · PMID 33627673 · open access

Questions about rs61870251

What is rs61870251?

rs61870251 is a single position in the genome, in or near the LHPP gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61870251 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs61870251 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61870251 come from?

GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glaucoma (primary open-angle) (rs61870251). MyGeneLog™. https://www.mygenelog.com/variants/rs61870251

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