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Who was studied 90,175 European ancestry cases, 366,152 European ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 8 × 10−10.
How common The A allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.
What each result means
A/ATwo copies of the version the research linked to Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment. This is the starting point the study compared everyone against.
Nature communications · 2021 · PMID 33608531 · open access
Questions about rs61787782
What is rs61787782?
rs61787782 is a single position in the genome, in or near the DPYD gene. Published research associates it with gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs61787782 linked to?
On MyGeneLog this position is linked to Peptic Ulcer Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs61787782 affect how medicines work?
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs61787782 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61787782 come from?
GWAS Catalog, Nature communications 2021, PMID:33608531. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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