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Monocyte count

NOS1AP · rs60441301

Where this position leads

Conditions: Monocyte Count, Blood Cell Counts

Drug: QT-prolonging medicines

rs60441301 Condition: Monocyte Count Monocyte Count Condition Condition: Blood Cell Counts Blood Cell Counts Condition Drug: QT-prolonging medicines QT-prolonging medicines Drug rs60441301 rs60441301 NOS1AP

What the study found

Who was studied 521,594 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0266 SD unit lower (95% confidence interval 0.022-0.032); p = 3 × 10−25.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.

What each result means

A/A Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/T No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
Source

Questions about rs60441301

What is rs60441301?

rs60441301 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs60441301 linked to?

On MyGeneLog this position is linked to Monocyte Count, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does rs60441301 affect how medicines work?

NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs60441301 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60441301 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Monocyte count (rs60441301). MyGeneLog™. https://www.mygenelog.com/variants/rs60441301

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