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NELL1 protein levels

NELL1 · rs58787811

Where this position leads

Condition: Celiac Disease

Drug: Hydrochlorothiazide

rs58787811 Condition: Celiac Disease Celiac Disease Condition Drug: Hydrochlorothiazide Hydrochlorothiazide Drug rs58787811 rs58787811 NELL1

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−42, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.168 higher (95% confidence interval 0.14-0.19); p = 7 × 10−43.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 11, band 11p15.1 — in an intron of NELL1.

What each result means

A/A Two copies of the version the research linked to NELL1 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to NELL1 protein levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to NELL1 protein levels. This is the starting point the study compared everyone against.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs58787811

What is rs58787811?

rs58787811 is a single position in the genome, in or near the NELL1 gene. Published research associates it with nell1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs58787811 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does rs58787811 affect how medicines work?

NELL1 carries pharmacogenomic findings for Hydrochlorothiazide. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs58787811 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58787811 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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NELL1 protein levels (rs58787811). MyGeneLog™. https://www.mygenelog.com/variants/rs58787811

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