Plasma 1-arachidonoyl-GPI (20:4)* levels in chronic kidney disease
SLCO1B1 · rs58258204
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Who was studied 4,960 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.124 higher (95% confidence interval 0.091-0.157); p = 6 × 10−13.
How common The T allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
C/CNo copy of the version the research linked to Plasma 1-arachidonoyl-GPI (20:4)* levels in chronic kidney disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Plasma 1-arachidonoyl-GPI (20:4)* levels in chronic kidney disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Plasma 1-arachidonoyl-GPI (20:4)* levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2023 · PMID 37277652 · open access
Questions about rs58258204
What is rs58258204?
rs58258204 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with plasma 1-arachidonoyl-gpi (20:4)* levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs58258204 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs58258204 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs58258204 come from?
GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3611822121Reads by AI crawlersClaude1ChatGPT1Google · Gemini0Perplexity0Meta AI8Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others21Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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