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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.214 higher (95% confidence interval 0.18-0.25); p = 7 × 10−33.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
A/ANo copy of the version the research linked to Total bilirubin levels (UKB data field 30840). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Total bilirubin levels (UKB data field 30840). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Total bilirubin levels (UKB data field 30840). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs577083514
What is rs577083514?
rs577083514 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with total bilirubin levels (ukb data field 30840). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs577083514 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs577083514 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs577083514 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs577083514 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Total bilirubin levels (UKB data field 30840) (rs577083514). MyGeneLog™. https://www.mygenelog.com/variants/rs577083514