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Who was studied 376,097 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 7.17 z score higher; p = 8 × 10−13.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 17, band 17q21.31 — in an intron of MAPT.
What each result means
A/ATwo copies of the version the research linked to Feeling miserable. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Feeling miserable. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Feeling miserable. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs56280951
What is rs56280951?
rs56280951 is a single position in the genome, in or near the ACBD4 gene. Published research associates it with feeling miserable. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs56280951 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs56280951 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56280951 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 71213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others3Total7Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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