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X-16935 levels

SLCO1B1 · rs56148886

Where this position leads

Drugs: Statins, Ticagrelor

rs56148886 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs56148886 rs56148886 SLCO1B1

What the study found

Who was studied 7,804 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.15 higher (95% confidence interval 0.11-0.19); p = 1 × 10−16.

How common The C allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.

What each result means

C/C Two copies of the version the research linked to X-16935 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to X-16935 levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to X-16935 levels. This is the starting point the study compared everyone against.
Source

Questions about rs56148886

What is rs56148886?

rs56148886 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with x-16935 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs56148886 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs56148886 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56148886 come from?

GWAS Catalog, Nature genetics 2023, PMID:36635386. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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X-16935 levels (rs56148886). MyGeneLog™. https://www.mygenelog.com/variants/rs56148886

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