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Local histogram emphysema pattern

CYP2A6 · rs56113850

Where this position leads

Drug: Smoking cessation medicines

rs56113850 Drug: Smoking cessation medicines Smoking cessation medicines Drug Topic: Smoking and vaping Smoking and vaping Topic rs56113850 rs56113850 CYP2A6

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Local histogram emphysema pattern — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Local histogram emphysema pattern.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Local histogram emphysema pattern compared to the general population.
Source
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns
Castaldi PJ, Cho MH, San José Estépar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK
COPDGene Investigators
American journal of respiratory and critical care medicine · 2014 · PMID 25006744

What people read about alongside this

Smoking and vaping4

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs56113850

What is rs56113850?

rs56113850 is a single position in the genome, in or near the CYP2A6 gene. Published research associates it with local histogram emphysema pattern. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs56113850 affect how medicines work?

CYP2A6 carries pharmacogenomic findings for Smoking cessation medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs56113850?

Subjects that appear in the title or abstract of the same papers as this rsID include smoking and vaping (4 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs56113850 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56113850 come from?

GWAS Catalog, Am J Respir Crit Care Med 2014, PMID:25006744. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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