Standard

CD64 on CD14- CD16-

near HLA-DRB1 · rs558721

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 3,622 Sardinian (founder/genetic isolate) ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.333 higher (95% confidence interval 0.22-0.45); p = 2 × 10⁻⁸.

How common The T allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 12.9 kb from HLA-DRB1.

What each result means

C/C No copy of the version the research linked to CD64 on CD14- CD16-. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to CD64 on CD14- CD16-. That is a smaller link than two copies.

T/T Two copies of the version the research linked to CD64 on CD14- CD16-. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG

and 16 more — show all

Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F

Nature genetics · 2020 · PMID 32929287

Questions about rs558721

What is rs558721?

rs558721 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with cd64 on cd14- cd16-. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs558721 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs558721 come from?

GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

CD64 on CD14- CD16- (rs558721). MyGeneLog™. https://www.mygenelog.com/variants/rs558721

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