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Retinal vascular fractal density

near HLA-DRB1 · rs556025

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 38,932 British ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0394 higher (95% confidence interval 0.025-0.053); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 13.3 kb from HLA-DRB1.

What each result means

C/C No copy of the version the research linked to Retinal vascular fractal density. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Retinal vascular fractal density. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Retinal vascular fractal density. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature

Zekavat SM, Raghu VK, Trinder M, Ye Y, Koyama S, Honigberg MC, Yu Z, Pampana A, Urbut S, Haidermota S, O'Regan DP, Zhao H

and 10 more — show all

Ellinor PT, Segrè AV, Elze T, Wiggs JL, Martone J, Adelman RA, Zebardast N, Del Priore L, Wang JC, Natarajan P

Circulation · 2022 · PMID 34743558

Questions about rs556025

What is rs556025?

rs556025 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with retinal vascular fractal density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs556025 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs556025 come from?

GWAS Catalog, Circulation 2022, PMID:34743558. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Retinal vascular fractal density (rs556025). MyGeneLog™. https://www.mygenelog.com/variants/rs556025

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