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HDL cholesterol levels

CETP · rs545858676

Where this position leads

Drug: Statins

rs545858676 Drug: Statins Statins Drug rs545858676 rs545858676 CETP

What the study found

Who was studied 403,943 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0975 higher (95% confidence interval 0.086-0.109); p = 1 × 10−58.

How common The A allele had a frequency of about 96% in the people studied.

Where it sits Chromosome 16, band 16q13 — in an intron of CETP.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HDL cholesterol levels compared to the general population.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HDL cholesterol levels.
C/C Published research associates this genotype with typical/baseline likelihood of HDL cholesterol levels — no copies of the reported risk allele.
Source
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV
PLoS medicine · 2020 · PMID 32203549 · open access

Questions about rs545858676

What is rs545858676?

rs545858676 is a single position in the genome, in or near the CETP gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs545858676 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs545858676 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs545858676 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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HDL cholesterol levels (rs545858676). MyGeneLog™. https://www.mygenelog.com/variants/rs545858676

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