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Who was studied 372,869 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.34 lower; p = 2 × 10−10.
How common The T allele had a frequency of about 29% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — a missense change in NOTCH4.
What each result means
C/CNo copy of the version the research linked to Feeling worry. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Feeling worry. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Feeling worry. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs520692
What is rs520692?
rs520692 is a single position in the genome, in or near the C4A gene. Published research associates it with feeling worry. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs520692 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs520692 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs520692 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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