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Who was studied 372,047 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.72 z score higher; p = 2 × 10−11.
How common The T allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 7, band 7q31.33 — between genes, 238.9 kb from GRM8.
What each result means
C/CNo copy of the version the research linked to Feeling hurt. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Feeling hurt. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Feeling hurt. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs500976
What is rs500976?
rs500976 is a single position in the genome, in or near the near GRM8 gene. Published research associates it with feeling hurt. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs500976 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs500976 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs500976 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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