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Type 2 diabetes with ophthalmic manifestations (PheCode 250.23)

near ANK1 · rs4737000

Where this position leads

Condition: Type 2 Diabetes

rs4737000 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs4737000 rs4737000 near ANK1

What the study found

Who was studied 11,204 African American or Afro-Caribbean cases, 103,814 African American or Afro-Caribbean controls, 5,479 Hispanic or Latin American cases, 51,558 Hispanic or Latin American controls, 459 East Asian ancestry cases, 6,108 East Asian ancestry controls, 28,561 European ancestry cases, 402,796 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0666 lower (95% confidence interval 0.052-0.081); p = 3 × 10−16.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 8, band 8p11.21 — between genes, 1 kb from ANK1.

What each result means

A/A Two copies of the version the research linked to Type 2 diabetes with ophthalmic manifestations (PheCode 250.23). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Type 2 diabetes with ophthalmic manifestations (PheCode 250.23). That is a smaller link than two copies.
C/C No copy of the version the research linked to Type 2 diabetes with ophthalmic manifestations (PheCode 250.23). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4737000

What is rs4737000?

rs4737000 is a single position in the genome, in or near the near ANK1 gene. Published research associates it with type 2 diabetes with ophthalmic manifestations (phecode 250.23). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4737000 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs4737000 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4737000 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes with ophthalmic manifestations (PheCode 250.23) (rs4737000). MyGeneLog™. https://www.mygenelog.com/variants/rs4737000

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