CCND3 · rs4711698
Where this position leads
Conditions: Blood Cell Counts, Monocyte Count
Strength of the evidence
Its strongest genetic-study result is p = 10−28, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 234,690 European ancestry individuals; replicated in 100,494 European ancestry individuals.
The effect The reported allele is C; the catalogue records no effect size ; p = 9 × 10−29.
How common The C allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 6, band 6p21.1 — in an intron of CCND3.
rs4711698 is a single position in the genome, in or near the CCND3 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Cell Counts, Monocyte Count. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Monocyte count (rs4711698). MyGeneLog™. https://www.mygenelog.com/variants/rs4711698