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Type 2 diabetes (PheCode 250.2)

near TMEM154 · rs4696136

Where this position leads

Condition: Type 2 Diabetes

rs4696136 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs4696136 rs4696136 near TMEM154

What the study found

Who was studied 51,551 African American or Afro-Caribbean cases, 64,463 African American or Afro-Caribbean controls, 22,274 Hispanic or Latin American cases, 35,406 Hispanic or Latin American controls, 2,272 East Asian ancestry cases, 4,333 East Asian ancestry controls, 154,194 European ancestry cases, 278,454 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0414 higher (95% confidence interval 0.03-0.053); p = 1 × 10−13.

How common The C allele had a frequency of about 62% in the people studied.

Where it sits Chromosome 4, band 4q31.3 — between genes, 21.5 kb from TMEM154.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes (PheCode 250.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Type 2 diabetes (PheCode 250.2). That is a smaller link than two copies.
T/T No copy of the version the research linked to Type 2 diabetes (PheCode 250.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4696136

What is rs4696136?

rs4696136 is a single position in the genome, in or near the near TMEM154 gene. Published research associates it with type 2 diabetes (phecode 250.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4696136 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs4696136 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4696136 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (PheCode 250.2) (rs4696136). MyGeneLog™. https://www.mygenelog.com/variants/rs4696136

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