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Chronic renal failure [CKD] (PheCode 585.3)

USP38 · rs4690780

Where this position leads

Condition: Chronic Renal Failure (CKD)

rs4690780 Condition: Chronic Renal Failure (CKD) Chronic Renal Failure (CKD) Condition rs4690780 rs4690780 USP38

What the study found

Who was studied 21,844 African American or Afro-Caribbean cases, 94,448 African American or Afro-Caribbean controls, 6,385 Hispanic or Latin American cases, 51,716 Hispanic or Latin American controls, 708 East Asian ancestry cases, 5,957 East Asian ancestry controls, 63,705 European ancestry cases, 368,937 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0469 higher (95% confidence interval 0.034-0.06); p = 1 × 10−13.

How common The C allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 4, band 4q31.21 — in an intron of USP38.

What each result means

C/C Two copies of the version the research linked to Chronic renal failure [CKD] (PheCode 585.3). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Chronic renal failure [CKD] (PheCode 585.3). That is a smaller link than two copies.
T/T No copy of the version the research linked to Chronic renal failure [CKD] (PheCode 585.3). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4690780

What is rs4690780?

rs4690780 is a single position in the genome, in or near the USP38 gene. Published research associates it with chronic renal failure [ckd] (phecode 585.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4690780 linked to?

On MyGeneLog this position is linked to Chronic Renal Failure (CKD). The research behind each link, and its sources, are set out on that condition page.

Does having rs4690780 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4690780 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronic renal failure [CKD] (PheCode 585.3) (rs4690780). MyGeneLog™. https://www.mygenelog.com/variants/rs4690780

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