Chronic Renal Failure (CKD), as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 92,642 cases and 521,058 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Chronic Renal Failure (CKD) — filed in the GWAS Catalog as "Chronic renal failure [CKD] (PheCode 585.3)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 2 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 92,642 cases and 521,058 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). From it, 2 positions on this page: rs2622821 (near ADAMTS7), rs4690780 (USP38). PMID:39024449.
The catalogue maps the 2 positions to 2 genes: ADAMTS7, USP38. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Verma A et al. 2024 reported the smallest P value on this page — P = 2 × 10-14 — at rs2622821 near ADAMTS7.
It is a record of what genome-wide studies have reported about Chronic Renal Failure (CKD), kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Chronic Renal Failure (CKD). The 2 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Chronic Renal Failure (CKD) comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Chronic Renal Failure (CKD). MyGeneLog™. https://www.mygenelog.com/conditions/chronic-renal-failure-ckd
Chronic Renal Failure (CKD) is the condition the GWAS Catalog files under "Chronic renal failure [CKD] (PheCode 585.3)". This page does not define it in its own words; it lists what genome-wide studies have reported: 2 positions from 1 study, with each study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 92,642 cases and 521,058 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 2 genes: ADAMTS7, USP38. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Chronic Renal Failure (CKD) from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.