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Cerebrospinal fluid protein SELP levels

F5 · rs4656688

Where this position leads

What the study found

Who was studied 2,524 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.205 higher (95% confidence interval 0.15-0.26); p = 9 × 10⁻¹⁵.

How common The C allele had a frequency of about 52% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — in an intron of F5.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-11-10. ClinVar record 1289282 NM_000130.5(F5):c.731-195G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version the research linked to Cerebrospinal fluid protein SELP levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Cerebrospinal fluid protein SELP levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Cerebrospinal fluid protein SELP levels. This is the starting point the study compared everyone against.

Source

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I

and 12 more — show all

Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C

Science translational medicine · 2026 · PMID 42054495

Questions about rs4656688

What is rs4656688?

rs4656688 is a single position in the genome, in or near the F5 gene. Published research associates it with cerebrospinal fluid protein selp levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs4656688 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs4656688 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4656688 come from?

GWAS Catalog, Science translational medicine 2026, PMID:42054495. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebrospinal fluid protein SELP levels (rs4656688). MyGeneLog™. https://www.mygenelog.com/variants/rs4656688

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