Sensitive

Testicular germ cell tumor

SPRY4 · rs4624820

Where this position leads

Condition: Testicular Germ Cell Tumour

rs4624820 Condition: Testicular Germ Cell Tumour Testicular Germ Cell Tumour Condition rs4624820 rs4624820 SPRY4

What the study found

Who was studied 730 cases, 1,435 controls; replicated in 571 cases, 1,806 controls.

The effect Each copy of the A allele carried 1.37 times the odds of Testicular germ cell tumor (95% confidence interval 1.19-1.58); p = 3 × 10−13.

How common The A allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 5, band 5q31.3 — between genes, 8.2 kb from SPRY4.

What each result means

A/A Two copies of the version the research linked to Testicular germ cell tumor. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Testicular germ cell tumor. That is a smaller link than two copies.
G/G No copy of the version the research linked to Testicular germ cell tumor. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4624820

What is rs4624820?

rs4624820 is a single position in the genome, in or near the SPRY4 gene. Published research associates it with testicular germ cell tumor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4624820 linked to?

On MyGeneLog this position is linked to Testicular Germ Cell Tumour. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs4624820?

Subjects that appear in the title or abstract of the same papers as this rsID include fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4624820 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4624820 come from?

GWAS Catalog, Nat Genet 2009, PMID:19483681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Testicular germ cell tumor (rs4624820). MyGeneLog™. https://www.mygenelog.com/variants/rs4624820

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