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Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.168 higher (95% confidence interval 0.15-0.18); p = 1 × 10−97.
Where it sits Chromosome 4, band 4q22.1 — in an intron of ABCG2.
What each result means
C/CTwo copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Urate levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs45570646
What is rs45570646?
rs45570646 is a single position in the genome, in or near the ABCG2 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs45570646 affect how medicines work?
ABCG2 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs45570646 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs45570646 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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