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Who was studied 57,290 European ancestry cases, 324,430 European ancestry controls, 2,302 African American cases, 29,223 African American controls, 1,656 Hispanic or Latin American cases, 10,819 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 0.0496 higher (95% confidence interval 0.035-0.065); p = 1 × 10−10.
How common The G allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 6, band 6p22.1 — between genes, 1.8 kb from SUMO2P1.
What each result means
G/GTwo copies of the version the research linked to Age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Age-related macular degeneration. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Age-related macular degeneration. This is the starting point the study compared everyone against.
rs444189 is a single position in the genome, in or near the near SUMO2P1 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs444189 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs444189 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs444189 come from?
GWAS Catalog, Nature genetics 2024, PMID:39623103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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