Primary open angle glaucoma (multi-trait analysis)
KANK2 · rs440677
0 1213215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot3Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied at least 29,241 European ancestry cases, at least 350,181 European ancestry controls (MTAG boosted by vertical cup-to-disc ratio and intraocular pressure samples), 6,935 Asian ancestry cases, 39,588 Asian ancestry controls, 3,281 African ancestry cases, 2,791 African ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0502 higher (95% confidence interval 0.035-0.066); p = 4 × 10−10.
Where it sits Chromosome 19, band 19p13.2 — in an intron of KANK2.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-12.
ClinVar record 1295450NM_001136191.3(KANK2):c.1849-22C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Primary open angle glaucoma (multi-trait analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Primary open angle glaucoma (multi-trait analysis). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Primary open angle glaucoma (multi-trait analysis). This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 37386247 · open access
Questions about rs440677
What is rs440677?
rs440677 is a single position in the genome, in or near the KANK2 gene. Published research associates it with primary open angle glaucoma (multi-trait analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs440677 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs440677 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs440677 come from?
GWAS Catalog, Nature genetics 2023, PMID:37386247. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1213215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot3Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Primary open angle glaucoma (multi-trait analysis) (rs440677). MyGeneLog™. https://www.mygenelog.com/variants/rs440677