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Who was studied 434,794 European ancestry female individuals.
The effect
Each copy of the T allele shifted the measure 0.0146 lower (95% confidence interval 0.011-0.019); p = 4 × 10−13.
How common The T allele had a frequency of about 79% in the people studied.
Where it sits Chromosome 1, band 1p21.3 — in a non-coding transcript of LOC100419654.
What each result means
C/CNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Human molecular genetics · 2019 · PMID 30239722 · open access
Questions about rs4379706
What is rs4379706?
rs4379706 is a single position in the genome, in or near the DPYD gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4379706 linked to?
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Does rs4379706 affect how medicines work?
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4379706 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4379706 come from?
GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4232118223119Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs4379706). MyGeneLog™. https://www.mygenelog.com/variants/rs4379706