Sensitive

Type 1 diabetes

BTN3A1 · rs4320356

Where this position leads

What the study found

Who was studied 1,005 Han Chinese ancestry cases, 1,257 Han Chinese ancestry controls; replicated in 1,378 Han Chinese ancestry cases, 3,774 Han Chinese ancestry controls.

The effect Each copy of the T allele carried 1.26 times the odds of Type 1 diabetes (95% confidence interval 1.16-1.36); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — in an intron of BTN2A3P.

What each result means

C/C No copy of the version the research linked to Type 1 diabetes. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Type 1 diabetes. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Type 1 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study

Zhu M, Xu K, Chen Y, Gu Y, Zhang M, Luo F, Liu Y, Gu W, Hu J, Xu H, Xie Z, Sun C

and 42 more — show all

Li Y, Sun M, Xu X, Hsu HT, Chen H, Fu Q, Shi Y, Xu J, Ji L, Liu J, Bian L, Zhu J, Chen S, Xiao L, Li X, Jiang H, Shen M, Huang Q, Fang C, Li X, Huang G, Fan J, Jiang Z, Jiang Y, Dai J, Ma H, Zheng S, Cai Y, Dai H, Zheng X, Zhou H, Ni S, Jin G, She JX, Yu L, Polychronakos C, Hu Z, Zhou Z, Weng J, Weng J, Shen H, Yang T

Diabetes care · 2019 · PMID 31152121

Questions about rs4320356

What is rs4320356?

rs4320356 is a single position in the genome, in or near the BTN3A1 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4320356 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs4320356 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4320356 come from?

GWAS Catalog, Diabetes Care 2019, PMID:31152121. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (rs4320356). MyGeneLog™. https://www.mygenelog.com/variants/rs4320356

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