4 4442114222125Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,157 European ancestry cases, 1,150 European ancestry controls; replicated in 7,892 European ancestry cases, 5,998 European ancestry controls, 678 Japanese ancestry cases, 336 Japanese ancestry controls.
The effect
Each copy of the G allele carried 2.16 times the odds of Age-related macular degeneration (95% confidence interval 1.84-2.53); p = 3 × 10−21.
How common The G allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of SKIC2.
What ClinVar records
Classificationnot provided; no classification provided (0 of 4 stars, 1 submitter).
ClinVar record 162167NM_006929.5(SKIC2):c.1212-29G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Age-related macular degeneration. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Age-related macular degeneration. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs429608
What is rs429608?
rs429608 is a single position in the genome, in or near the CFB gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs429608 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs429608?
Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs429608 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs429608 come from?
GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4442114222125Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total44Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.